Correction of metabolic disturbances by functional food compositions in experimental obesity in CD-1 and agouti-yellow mice

Background: To determine the most promising composition, possibility of correction metabolic disturbances was investigated with use functional food compositions in CD1 and agouti-yellow mice experimental obesity.Methods: Agouti-yellow were divided into 10 groups (control, 1/1, 1/9, 2/1, 2/9 each line) according to diets. For 4 weeks, ate a high-calorie diet. Starting week 5th, composition 1 added diet 1/1 (60% lard + 39% standard laboratory feed 1% 10% fructose solution), 1/9 31% 9% solution); 2 2/1 solution). On day 56th, animal weighed, blood taken for biochemical analysis (glucose, LDL, cholesterol HDL) organs (the skin anterior abdominal wall, skeletal muscle tissue area lateral surface thigh, liver, kidneys perirenal tissue, pancreas, thymus) histological examination.Results: In mice, group 2/9, greatest decrease glucose level observed compared control by 34.6% (p < 0.05). Consumption led significant LDL total 21.9% 0.05) 18.8% respectively group. HDL significantly higher than CD-1 showed best result (mean 5.78 mmol/l) among all receiving The pronounced value exceeded mean group, 54.8% Body mass decreased groups. According results examination tissues, turned out be promising.Conclusion: study, selected (composition 2). Feeding animals this improved pictures studied parameters effectively reduced body both lines, CD-1, Keywords: obesity,